Journal article
The relative and interactive impact of multiple risk factors in schizophrenia spectrum disorders: A combined register-based and clinical twin study
C Lemvigh, R Brouwer, R Hilker, S Anhoj, L Baandrup, C Pantelis, B Glenthoj, B Fagerlund
Psychological Medicine | Published : 2023
Abstract
Background Research has yielded evidence for genetic and environmental factors influencing the risk of schizophrenia. Numerous environmental factors have been identified; however, the individual effects are small. The additive and interactive effects of multiple risk factors are not well elucidated. Twin pairs discordant for schizophrenia offer a unique opportunity to identify factors that differ between patients and unaffected co-twins, who are perfectly matched for age, sex and genetic background. Methods Register data were combined with clinical data for 216 twins including monozygotic (MZ) and dizygotic (DZ) proband pairs (one or both twins having a schizophrenia spectrum diagnosis) and ..
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Awarded by Lundbeck Foundation
Awarded by NHMRC Senior Principal Research Fellowship
Funding Acknowledgements
The authors thank all the participants who took the time and effort to take part in this study. Moreover, they acknowledge research assistant Mikkel Erlang Sorensen (MSc), research nurse Helle Schaebel (CRN), medical doctor Christian Legind (Ph.D.), and psychologist Maria Hoj Jensen (Ph.D.) for valuable contributions to the recruitment and data collection. The study was supported by a PhD grant from the Mental Health Services in the Capital Region of Denmark to CKL, and Lundbeck Foundation grants (25-A2701, R155-2013-16337) for the Vulnerability Indicators of Psychosis study. CP was supported by a NHMRC Senior Principal Research Fellowship (1105825), and by a grant from the Lundbeck Foundation (ID: R246-2016-3237).